Test-retest Reproducibility of [11C]PHNO PET Using the Constant Infusion Paradigm
Status:
Completed
Trial end date:
2013-07-01
Target enrollment:
Participant gender:
Summary
A research study designed to examine amphetamine-induced dopamine release using the PET
imaging agent [11C]PHNO in tobacco smokers while currently smoking and during acute
withdrawal and in nonsmokers. Twenty healthy men and women tobacco smokers and twenty healthy
nonsmokers will be recruited. Each subject will participate in 1 MRI and up to 2 [11C]PHNO
PET scans. On the study day subjects will participate in two [11C]PHNO scans (ideally, the
two PET scans will be carried out in the same day). Three hours before the second PET scan,
amphetamine (0.5 mg/kg, PO) will be administered. In smokers, the scan will occur at 10-21
days of smoking abstinence.
Phase:
N/A
Details
Lead Sponsor:
Yale University
Collaborators:
National Cancer Institute (NCI) National Institute of Mental Health (NIMH)